6, 15 September 2014 | Nucleic Acids Research, Vol. 32, No. 26, No. 7, 25 June 2008 | Environmental Science and Pollution Research, Vol. Zebrafish embryos exhibit unique characteristics, including ease of maintenance and drug administration, short reproductive cycle, and transparency that permits visual assessment of developing cells and organs. Zebrafish as a Successful Animal Model for Screening Toxicity of Medicinal Plants. The zebrafish embryo has become an important vertebrate model for assessing drug effects. 2, 9 February 2010 | Tissue Engineering Part B: Reviews, Vol. 233, No. 2, 11 January 2016 | Journal of Biophotonics, Vol. 6, 21 February 2020 | ACS Chemical Neuroscience, Vol. The zebrafish model organism is ... potentially unsafe compounds rapidly in the early stages of drug development and to prioritize compounds for further preclinical and clinical studies. 3, IEEE Transactions on Automation Science and Engineering, Vol. 1, 25 March 2019 | Natural Product Communications, Vol. 34, No. Abstract: The traditional drug discovery pipeline for the identification and development of compounds that selectively target specific molecules to ameliorate disease remains a major focus for medical research. Enter your email address below and we will send you the reset instructions. 4, 27 September 2016 | Scientific Reports, Vol. 10, 27 April 2007 | Pharmacology, Vol. Overall, zebrafish-based test systems have to be validated carefully by comparing them to established protocols. If the address matches an existing account you will receive an email with instructions to reset your password. Preclinical screening with animal models is an important initial step in clinical translation of new drug delivery systems. 1, 24 August 2010 | Journal of Applied Toxicology, Vol. Angiogenesis. 7, 20 May 2013 | Journal of Applied Toxicology, Vol. 87, No. A zebrafish model for ototoxicity may fill this gap in preclinical safety testing. 9, 2 July 2018 | Advanced Healthcare Materials, Vol. Sci Rep 9 9615 PMID: 31270336 . 1, Toxicology and Applied Pharmacology, Vol. detected using a zebrafish Tuebingen embryo model, Rapid identification of antimicrometastases drugs using integrated model systems with two dimensional monolayer, three dimensional spheroids, and zebrafish xenotransplantation tumors, Silver Nanoparticles Synthesized Using Eysenhardtia polystachya and Assessment of the Inhibition of Glycation in Multiple Stages In Vitro and in the Zebrafish Model, Understanding the Role of Environmental Enrichment in Zebrafish Neurobehavioral Models, Leaves of Spondias mombin L. a traditional anxiolytic and antidepressant: Pharmacological evaluation on zebrafish (Danio rerio), Model organism data evolving in support of translational medicine, Adaptation of a visible wavelength fluorescence microplate reader for discovery of near-infrared fluorescent probes, Using Ultrafast Responsive Phosphorescent Nanoprobe to Visualize Elevated Peroxynitrite In Vitro and In Vivo via Ratiometric and Time-Resolved Photoluminescence Imaging, Zebrafish as a Model to Evaluate Nanoparticle Toxicity, Understanding taurine CNS activity using alternative zebrafish models, Toxicity of porcelain-fused-to-metal substrate to zebrafish ( Danio rerio ) embryos and larvae, Excitation and Excitation-Contraction Coupling of the Zebrafish Heart: Implications for the Zebrafish Model in Drug Screening, Selective IKK2 inhibitor IMD0354 disrupts NF-κB signaling to suppress corneal inflammation and angiogenesis, A Simple Setup to Perform 3D Locomotion Tracking in Zebrafish by Using a Single Camera, Copper-containing mesoporous bioactive glass promotes angiogenesis in an in vivo zebrafish model, Orthosiphon stamineus Leaf Extract Affects TNF-α and Seizures in a Zebrafish Model, Alleviating the hepatotoxicity of trazodone via supramolecular encapsulation, Zebrafish Model for Investigating the Integrated Control of Reproduction, The developing utility of zebrafish models of neurological and neuropsychiatric disorders: A critical review, Microfluidics for mechanobiology of model organisms, Activity of gallic acid and its ester derivatives in 39, 17 August 2012 | Annals of the New York Academy of Sciences, Vol. The effects of compounds on various organs, including the heart, brain, intestine, pancreas, cartilage, liver, and kidney, were observed in the transparent animals without complicated processing, demonstrating the efficiency of toxicity assays using zebrafish embryos. 19, pp. 2007 Summer;4(2):113-6. doi: 10.1089/zeb.2007.0508. ), GBR12909 Possesses Anticonvulsant Activity in Zebrafish and Rodent Models of Generalized Epilepsy but Cardiac Ion Channel Effects Limit Its Clinical Utility, Human melanoma cells transplanted into zebrafish proliferate, migrate, produce melanin, form masses and stimulate angiogenesis in zebrafish, Small molecule screening in the zebrafish, A zebrafish assay for identifying neuroprotectants in vivo, Use of nontraditional animals for evaluation of pharmaceutical products, Sequence Analysis and Functional Study of Thymidylate Synthase from Zebrafish, Danio rerio, Homology-Modeled Ligand-Binding Domains of Zebrafish Estrogen Receptors α, β1, and β2: From in Silico to in Vivo Studies of Estrogen Interactions in Danio rerio as a Model System, The use of zebrafish for assessing ototoxic and otoprotective agents, Zebrafish as a Model Vertebrate for Investigating Chemical Toxicity, Pharmacology and toxicology of pahayokolide A, a bioactive metabolite from a freshwater species of isolated from the Florida Everglades, Functional Genomics Tools for the Analysis of Zebrafish Pigment, In vivo biofluid dynamic imaging in the developing zebrafish, Zebrafish Apoptosis Assays for Drug Discovery, Zebrafish: An Animal Model for Toxicological Studies, Inhibitors of cyclin-dependent kinase modulators for cancer therapy, http://doi.org/10.1089/154065802761001293. Zebrafish platform Austria for preclinical drug screening (ZANDR) Zebrafish and in particular zebrafish larvae is a well suited vertebrate model system to investigate various human diseases and to perform cost-effective screens for small molecules with therapeutic potential (1). 2, 26 April 2011 | Biomedical Optics Express, Vol. New drug combination disrupts leukemia cells in preclinical studies; Massey director awarded $3.2M to inform the development of novel therapies for blood disorders; Samantha Harris to keynote Women & Wellness Signature Breakfast and Luncheon; Massey biologist studies role of lipids in the development of lung cancer and resistance to chemotherapy 10, Review of Scientific Instruments, Vol. 1, 14 September 2016 | Protein Science, Vol. 357, No. Danio rerio 4, 26 September 2007 | Expert Opinion on Drug Discovery, Vol. 11, No. Dissertations & Theses from 2019. 139, No. Human amniotic fluid stem cells (hAFSCs) are multipotent cells that have ability to inhibit cell apoptosis. 228, No. 12, 4 November 2020 | ACS Applied Bio Materials, Vol. The survival rate among children with relapsed neuroblastomas continues to be poor, and thus new therapeutic approaches identified by reliable preclinical drug testing models are urgently needed. 79A, No. The small size and the high number of the zebrafish progeny allow the parallel and reproducible testing of several drugs and dosages in simple multiwell plates. Plants (Basel). In this review, current understanding of the epidemiology, genetics, pathology and pathogenesis of Alzheimer's disease is outlined, before its clinical presentation and current treatment strategies are discussed. We also demonstrated that in vivo acridine orange staining can be used to visualize apoptotic events in embryos treated with brefeldin A, neomycin, or caspase inhibitors. BioReperia, based in Sweden and Switzerland, offers a highly precise, humanized zebrafish model to the pharmaceutical industry, to evaluate the safety and efficacy of oncology drug candidates in vivo, getting results as early as within a week. Magnolia officinalis COVID-19 is an emerging, rapidly evolving situation. 39, No. 3, 10 June 2011 | Birth Defects Research Part C: Embryo Today: Reviews, Vol. 27, No. Alpinia officinarum 100, 6 March 2019 | Expert Opinion on Drug Discovery, Vol. 3, 1 November 2003 | Current Protocols in Toxicology, Vol. inhibition of the VEGFR-2 signaling pathway, Adaptation of a Mice Doppler Echocardiography Platform to Measure Cardiac Flow Velocities for Embryonic Chicken and Adult Zebrafish, Modeling gut-brain interactions in zebrafish, Zebrafish models for attention deficit hyperactivity disorder (ADHD), Clostridium perfringens Epsilon Toxin Compromises the Blood-Brain Barrier in a Humanized Zebrafish Model, Screening drugs for myocardial disease in vivo with zebrafish: an expert update, Food colorant Sunset Yellow (E110) intervenes developmental profile of zebrafish ( Dissertations & Theses from 2018. 2, 7 June 2012 | Metabolic Brain Disease, Vol. For instance, in a chemical genetic screen testing 2.480 compounds, prostaglandin E2 (PGE2) was identified as an evolutionarily conserved regulator of 52, No. Functional Hybrid Nanoemulsions for Sumatriptan Intranasal Delivery. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. ), Cytoprotective activities of water-soluble fullerenes in zebrafish models, N-Acetylchitooligosaccharide is a potent angiogenic inhibitor both in vivo and in vitro, The Effects of Aromatase Inhibitors and Selective Estrogen Receptor Modulators on Eye Development in the Zebrafish ( 12, 5 October 2018 | BMC Complementary and Alternative Medicine, Vol. 18, No. Zebrafish embryos exhibit unique characteristics, including ease of maintenance and drug administration, short reproductive cycle, and transparency that permits visual assessment of developing cells and organs. Zebrafish CROs, such as ZeClinics, are collaborating with the US National Institutes of Health (NIH), the Environmental Protection Agency (EPA), the National Toxicology Program (NTP), corporations, and academic groups in the SEAZIT global project, aimed at broadening the adoption of the zebrafish model and harmonizing protocols for preclinical toxicological screenings. 201, Journal of Drug Delivery Science and Technology, Vol. # Zebrafish # preclinical model # drug screening; ... IND vs AUS, 3rd Test Highlights, Day 1 Australia ने Sydney में बनाए 166/2, Rishabh Pant ने छोड़े 2 अहम कैच, फैन्स ने लगा दी क्लास – Watch Video . As shown in Fig. Cancer Res. Alzheimer's disease, the commonest cause of dementia, is a growing global health concern with huge implications for individuals and society. 2, 4 March 2010 | British Journal of Pharmacology, Vol. 5, Behavioural Brain Research, Vol. 422, No. In vivo zebrafish assays for analyzing drug toxicity. Here we describe the use of zebrafish bioassays for assessing toxicity, angiogenesis, and apoptosis. 6, 4 May 2011 | Cytometry Part A, Vol. Critical parameters of zebrafish experiments 3, No. Here we describe the use of zebrafish bioassays for assessing toxicity, angiogenesis, and apoptosis. 11, 8 September 2018 | Journal of Cluster Science, Vol. 4, 19 October 2004 | Birth Defects Research Part C: Embryo Today: Reviews, Vol. A macro trend in drug discovery is the use of complex models of disease early in preclinical studies. 3, Biochemical and Biophysical Research Communications, Vol. 21, No. 2019, Ecotoxicology and Environmental Safety, Vol. 12, No. 2, No. Specifically, others and we believe that the use of zebrafish for the study of behavioral endophenotypes of psychiatric disorders and addiction can be uniquely advantageous [11] , [13] , [68] – [71] . 11, No. 4, Science of The Total Environment, Vol. 46, No. The zebrafish embryo has become an important vertebrate model for assessing drug effects. 7, Neuroscience & Biobehavioral Reviews, Vol. 9, 1 October 2016 | Zebrafish, Vol. 17, No. After in vivo staining, acridine orange can be extracted and quantitated using a fluorescence microplate reader, providing a screening system for agents that modulate apoptosis. Keywords:Zebrafish, drug discovery, drug testing, large-scale screen, chemical genetics, pre-clinical studies. 4, 13 November 2018 | Journal of Applied Toxicology, Vol. Chuenlei Parng, Wen Lin Seng, Carlos Semino, and Patricia McGrath. 16, No. 2. 02, No. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username. 42, No. 4, 21 December 2019 | Microsystem Technologies, Vol. 10, Journal of Experimental Nanoscience, Vol. 5, 14 May 2019 | Frontiers in Bioengineering and Biotechnology, Vol. 293, No. Use of zebrafish apoptosis assays for preclinical drug discovery. 23, No.  |  14, 2 June 2016 | Journal of Liposome Research, Vol. In addition to studies in genetics and developmental biology, zebrafish has also been widely used in human disease modeling and drug screening. The versatile zebrafish is now incorporated in many areas of toxicological programs for assessing human risk and for preclinical drug discovery and screening. 2, Journal of Ethnopharmacology, Vol. Following a "drug repurposing" approach, we tested anti-trypanosomal effects of carbazole-derived compounds called "Curaxins". 93, No. 18, No. Rhus coriaria 2, No. It features a host of proprietary technologies that combine to deliver exceptional speed and operational simplicity, making your lab more efficient than ever before. 9, Investigative Opthalmology & Visual Science, Vol. ), Effects of 25 thyroid hormone disruptors on zebrafish embryos: A literature review of potential biomarkers, Biocompatibility Assessment of Nanomaterials Using Zebra Fish as a Model, Bioassay-Guided Isolation and Evaluation of Herbal Drugs, New Bis-Alkenoic Acid Derivatives from a Marine-Derived Fungus Fusarium solani H915, Comparative cardio and developmental toxicity induced by the popular medicinal extract of Sutherlandia frutescens (L.) R.Br. ) models, Toxicological profile and acetylcholinesterase inhibitory potential of Palicourea deflexa, a source of β-carboline alkaloids, Preparation and evaluation of PLGA nanoparticle-loaded biodegradable light-responsive injectable implants as a promising platform for intravitreal drug delivery, In vivo cardiovascular toxicity induced by acetochlor in zebrafish larvae, Zebrafish models for functional and toxicological screening of nanoscale drug delivery systems: promoting preclinical applications, Inhibition of vascular endothelial growth factor-induced angiogenesis by chlorogenic acid via targeting the vascular endothelial growth factor receptor 2-mediated signaling pathway, Measuring the mass, volume, and density of microgram-sized objects in fluid, The cyclin-like protein, SPY1, regulates the ERα and ERK1/2 pathways promoting tamoxifen resistance, Sensitization of multidrug-resistant malignant cells by liposomes co-encapsulating doxorubicin and chloroquine through autophagic inhibition, Size does matter – Determination of the critical molecular size for the uptake of chemicals across the chorion of zebrafish (Danio rerio) embryos, Protective effect of 735, Current Neurovascular Research, Vol. 1, Journal of Pharmacopuncture, Vol. Genesis Drug Discovery & Development (GD3) - fully integrated CRO with a diverse portfolio covering all areas of preclinical drug discovery/development as well as model development for a wide range of therapeutic areas. However, establishing efficacy, biodistribution, and biotoxicity of complex, multicomponent systems in small animal models can be expensive and time-consuming. 7, No. 32, No. 51, 1 January 2019 | Food & Function, Vol. 9, Journal of Drug Delivery Science and Technology, Vol. 10, No. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. 16, No. a drug known to protect against vascular leakage in murine models, as a lead hit, thereby validating the utility of our model for sepsis drug screens. Wang YF, Chen IW, Subendran S, Kang CW, Panigrahi B, Fu TF, Chen CY. Generation and Application of the Zebrafish. It is well suited for studies in genetics, embryology, development, and cell biology. 5, 25 March 2013 | Developmental Dynamics, Vol. 15, No. 4, 24 May 2016 | Scientific Reports, Vol. 5, South African Journal of Botany, Vol. 11, No. Christopher M. Borges, et al. Would you like email updates of new search results? Zebrafish are a powerful vertebrate model in preclinical cancer research. 5, 31 March 2008 | Oncogene, Vol. Author information: (1)Division of Genetics, Program in Genomics, Children's Hospital, Boston, MA 02115, USA. 11, Neuroscience & Biobehavioral Reviews, Vol. Automated, quantitative screening assay for antiangiogenic compounds using transgenic zebrafish. 3, 1 May 2006 | The Journal of Biochemistry, Vol. Edible additive effects on zebrafish cardiovascular functionality with hydrodynamic assessment. in vivo 1378, No. 9, No. Subergorgia suberosa USA.gov. Zebrafish and human auditory systems most likely share an evolutionary origin with those of all vertebrates. For example, only 5% of anti-cancer agents in preclinical development showed sufficient efficacy in phase III testing, although they showed efficacy in mouse models of cancer . 1, Birth Defects Research Part B: Developmental and Reproductive Toxicology, Vol. 121, No. 5, 23 February 2011 | Expert Opinion on Drug Metabolism & Toxicology, Vol. Zebrafish models represent an alternative for preclinical studies for nanoscale drug delivery systems. 1, 23 February 2018 | Frontiers in Pharmacology, Vol. 1-2, Regulatory Toxicology and Pharmacology, Vol. 1, 1 December 2008 | Expert Opinion on Drug Discovery, Vol. Furthermore, Cur micelles were more effective in inhibiting tumor growth and prolonged survival in both s.c. and pulmonary metastatic LL/2 tumor models. 4, No. As a result, these can lead to the identification of candidate substances that are further examined in preclinical and clinical trials. 31, No. Animal models are important for screening drugs but the right animal model(s) need(s) to be selected. Rasul A, Imran Khan M, Rehman MU, Abbas G, Aslam N, Ahmad S, Abbas K, Akhtar Shah P, Iqbal M, Ahmed Al Subari AM, Shaheer T, Shah S. International Journal of Nanomedicine 2020, 15:7937-7949 A rapid apoptosis assay measuring relative acridine orange fluorescence in zebrafish embryos. A macro trend in drug discovery is the use of complex models of disease early in preclinical studies. 6, 3 April 2020 | Scientific Reports, Vol. 4, 19 December 2011 | Oncogene, Vol. 121, No. 10, No. Interactions of PPAR-alpha and adenosine receptors in hypoxia-induced angiogenesis, Acetyl l-carnitine protects motor neurons and Rohon-Beard sensory neurons against ketamine-induced neurotoxicity in zebrafish embryos, Proline-induced changes in acetylcholinesterase activity and gene expression in zebrafish brain: Reversal by antipsychotic drugs, Ketamine induces motor neuron toxicity and alters neurogenic and proneural gene expression in zebrafish, A category approach to predicting the developmental (neuro) toxicity of organotin compounds: The value of the zebrafish (Danio rerio) embryotoxicity test (ZET), The Role of Cyclooxygenases and Lipoxygenases in the Regulation of Tumor Angiogenesis, Zebrafish embryos as an alternative model for screening of drug-induced organ toxicity, 3D quantitative analyses of angiogenic sprout growth dynamics, Set-up of an infrared fast behavioral assay using zebrafish ( 4, 5 December 2014 | Toxin Reviews, Vol. 2, Journal of Ethnopharmacology, Vol. 90, 13 January 2018 | Angiogenesis, Vol. 160, No. © 2021 Mary Ann Liebert, Inc., publishers. 42, 12 November 2014 | Journal of Dental Research, Vol. Abdel-Salam, Ahmed Nabil (2018) … 13, No. Zebrafish embryos exhibit unique characteristics, including ease of maintenance and drug administration, short reproductive cycle, and transparency that permits visual assessment of developing cells and organs. 2, Journal of Ethnopharmacology, Vol. It is well suited for studies in genetics, embryology, development, and cell biology. Journal of Medicinal Chemistry 2021, 64, 1, 326-342 (Drug Annotation) ACS Editors' Choice Publication Date (Web) : December 24, 2020 In conclusion, the zebrafish presents a powerful in vivo preclinical model for assessing the adverse effects of a wide range of drugs as well as to determine drug efficacy. 27, No. 34, No. 2, Journal of Biomedical Research, Vol. Embryonic angiogenesis and tumor-induced angiogenesis were both dramatically inhibited by Cur micelles in transgenic zebrafish model. During the last two decades, the zebrafish has emerged as a valuable and efficient vertebrate model organism enabling large-scale in vivo small compound screening during the early 4, 19 October 2006 | Angiogenesis, Vol. 12, 3 December 2014 | Zebrafish, Vol. Specialized in the efficient development of your preclinical program. 79, No. 3, No. https://doi.org/10.1089/154065802761001293, A 3D Convolutional Neural Network for Bacterial Image Classification, Behavioral changes occur earlier than redox alterations in developing zebrafish exposed to Mancozeb, The effect of ginsenoside Rg5, isolated from black ginseng, on heart failure in zebrafish based on untargeted metabolomics, Zebrafish models of acute leukemias: Current models and future directions, Neuropeptide Y deficiency induces anxiety-like behaviours in zebrafish (Danio rerio), Edible additive effects on zebrafish cardiovascular functionality with hydrodynamic assessment, An acetylcholinesterase inhibitor, donepezil, increases anxiety and cortisol levels in adult zebrafish, Circumstantial Overdose Management of an Efficient Cancer Cell Photosensitizer with Preclinical Evidence: A Biophysical Study, Functional Hybrid Nanoemulsions for Sumatriptan Intranasal Delivery, Generation and Application of the Zebrafish heg1 Mutant as a Cardiovascular Disease Model, Efficacy of Ciprofloxacin/Celecoxib combination in zebrafish models of amyotrophic lateral sclerosis, Zebrafish as a Successful Animal Model for Screening Toxicity of Medicinal Plants, Ecotoxicological assessment of effluents from Brazilian wastewater treatment plants using zebrafish embryotoxicity test: A multi-biomarker approach, Antioxidant activity and zebrafish teratogenicity of hydroalcoholic 3, No. In a murine model of HAT, oral administration of compound 1 cured the disease. 3, Neurotoxicology and Teratology, Vol. Presented at the 62nd Annual Meeting and Exposition of the American Society of Hematology (ASH), December 5-8, 2020. 6, No. 2020 Oct 12;9(10):1345. doi: 10.3390/plants9101345. Extract and Its Constituents Magnolol and Honokiol Exhibit Potent Anticonvulsant Activity in a Therapy-Resistant Epilepsy Model, Evaluation of developmental toxicity and anti-angiogenic potential of essential oils from Moringa oleifera and Moringa peregrina seeds in zebrafish (Danio rerio) model, Animal Models Systems of Cancer for Preclinical Trials, Toxicity evaluation of sulfamides and coumarins that efficiently inhibit human carbonic anhydrases, Toxicity Assessment of Herbal Medicine Using Zebrafish Embryos: A Systematic Review, Ecotoxicological assessment and electrochemical remediation of doxorubicin, Promoting zebrafish embryo tool to identify the effects of chemicals in the context of Water Framework Directive monitoring and assessment, Design and synthesis of novel celastrol derivative and its antitumor activity in hepatoma cells and antiangiogenic activity in zebrafish, Preparation, toxicity analysis and in vivo protective effect of phyllanthin-loaded PLGA nanoparticles against CCl4-induced hepatic fibrosis, Cardiac Rhythm and Molecular Docking Studies of Ion Channel Ligands with Cardiotoxicity in Zebrafish, PHMH, a diarylheptanoid from 2, 11 June 2010 | Birth Defects Research Part C: Embryo Today: Reviews, Vol. 92, No. This saves both time and money in the very expensive process of Drug Discovery. 1, Evidence-Based Complementary and Alternative Medicine, Vol. Molecular testing and analyses of existing drug screen across 537 cancer cell lines validated mitochondrial protease ClpP and ATF4 as ONC201/6 targets. 5, 12 July 2010 | Journal of Cellular and Molecular Medicine, Vol. Danio rerio Expert Opin Drug Discov. Regulatory considerations of food-drug interactions 2.1. 31, No. 94, No. ) larvae, and its application in compound biotoxicity screening, Zebrafish: A nontraditional model of traditional medicine, Predictive Models and Computational Toxicology, Long-term proline exposure alters nucleotide catabolism and ectonucleotidase gene expression in zebrafish brain, Identification of phosphorylase kinase as a novel therapeutic target through high-throughput screening for anti-angiogenesis compounds in zebrafish, Zebrafish xenografts as a tool for in vivo studies on human cancer, Anti-angiogenic activity of thymoquinone by the down-regulation of VEGF using zebrafish (Danio rerio) model, Miniaturized Embryo Array for Automated Trapping, Immobilization and Microperfusion of Zebrafish Embryos, Anti-angiogenic effects and mechanisms of zerumin A from Alpinia caerulea, Screening of anti-cancer agent using zebrafish: Comparison with the MTT assay, Inter-laboratory assessment of a harmonized zebrafish developmental toxicology assay – Progress report on phase I, Developmental toxicity and endocrine disrupting potency of 4-azapyrene, benzo[b]fluorene and retene in the zebrafish Danio rerio, Behavioral profiling of zebrafish embryos exposed to a panel of 60 water-soluble compounds, Cynodon dactylon and Sida acuta extracts impact on the function of the cardiovascular system in zebrafish embryos, In Vitro-In Vivo Correlations in Drug Discovery and Development: Concepts and Applications in Toxicology, Developmental Exposure to Valproate and Ethanol Alters Locomotor Activity and Retino–Tectal Projection Area in Zebrafish Embryos, Zebrafish embryos and larvae in behavioural assays, Think Small: Zebrafish as a Model System of Human Pathology, Fish on Chips: Automated Microfluidic Living Embryo Arrays, The effects of astragalus polysaccharide on zebrafish cell apoptosis and senescence, ECVAM and New Technologies for Toxicity Testing, Cytoprotective Activities of Water-Soluble Fullerenes in Zebrafish Models, A Novel Preclinical Strategy for Identifying Cardiotoxic Kinase Inhibitors and Mechanisms of Cardiotoxicity, In vivo imaging and quantitative analysis of changes in axon length using transgenic zebrafish embryos, Wormometry-on-a-chip: Innovative technologies for in situ analysis of small multicellular organisms, Behavioral changes induced by long-term proline exposure are reversed by antipsychotics in zebrafish, COX-derived prostanoid pathways in gastrointestinal cancer development and progression: Novel targets for prevention and intervention, Bioenergetic Profiling of Zebrafish Embryonic Development, Gene expression of zebrafish embryos exposed to titanium dioxide nanoparticles and hydroxylated fullerenes, Zebrafish-As an integrative model for twenty-first century toxicity testing, Batch Transfer of Zebrafish Embryos Into Multiwell Plates, Large-Scale Assessment of the Zebrafish Embryo as a Possible Predictive Model in Toxicity Testing, Zebrafish embryos and larvae: A new generation of disease models and drug screens, In vivo fluorescence lifetime optical projection tomography, Design of novel artemisinin-like derivatives with cytotoxic and anti-angiogenic properties, Automated batch transfer of zebrafish embryos using a multi-degrees-of-freedom system, Zebrafish for drug toxicity screening: bridging the Channel Blocking in Zebrafish, ZebraBeat: a flexible platform for the analysis of the cardiac rate in zebrafish embryos, Synthesis, Anti-Tumor and Anti-Angiogenic Activity Evaluations of Asiatic Acid Amino Acid Derivatives, Study on early biomarkers of zebrafish liver injury induced by acetaminophen, Chick embryo chorioallantoic membrane (CAM): an alternative predictive model in acute toxicological studies for anti-cancer drugs, Zebrafish as a disease model for studying human hepatocellular carcinoma, Blocking VEGF Signaling Delays Development of Replacement Teeth in Zebrafish, Combining Motion Analysis and Microfluidics – A Novel Approach for Detecting Whole-Animal Responses to Test Substances, Transfer of Silica-Coated Magnetic (Fe3O4) Nanoparticles Through Food: A Molecular and Morphological Study in Zebrafish, Tumor-targeted in vivo gene silencing via systemic delivery of cRGD-conjugated siRNA, Comparison of toxicity values across zebrafish early life stages and mammalian studies: Implications for chemical testing, Extensive review of fish embryo acute toxicities for the prediction of GHS acute systemic toxicity categories, Ewing sarcoma inhibition by disruption of EWSR1-FLI1 transcriptional activity and reactivation of p53, Bioactive 9,11-Secosteroids from Gorgonian Key concepts and providing illustrative examples: 10.1517/17425255.2014.896339 models represent an Alternative preclinical! 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