CcmI Subunit of CcmFHI Heme Ligation Complex Functions as an Apocytochrome c Chaperone during c -Type Cytochrome Maturation. Electron carrier protein. Cytc also functions as a trigger of apoptosis when released into the cytosol. Because of its ubiquitous nature and sequence homology, cytochrome c has been used as a model protein for molecular evolution. Journal of Biological Chemistry 2011 , … Cytochrome c is a small protein associated with the inner membrane of the mitochondrion that functions as an essential part of the electron transport chain in aerobic respiration. Cytochrome c is primarily known for its function in the mitochondria as a key participant in the life-supporting function of ATP synthesis. It is the last protein in the electron transport chain.It receives an electron from each of four cytochrome c molecules, and transfers them to one oxygen molecule, converting molecular oxygen to two molecules of water. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Mammalian Cytochrome c (Cytc) is a multifunctional protein involved in cellular life and death decision. Other articles where Cytochrome c is discussed: cytochrome: …letters and numbers, such as cytochrome a3, cytochrome c, and cytochrome B562. Cytochrome c is the most stable and abundant member of the class, and it has been the most … Cytochrome c is a highly conserved ~12 kDa protein consisting of a single 104 amino acid peptide with a single heme group, which is covalently attached to Cys and Cys. Diseases associated with CYCS include Thrombocytopenia 4 and Autosomal Thrombocytopenia With Normal Platelets.Among its related pathways are Apoptosis Modulation and Signaling and Nur77 Signaling in T-Cell.Gene Ontology (GO) annotations related to this gene include iron ion binding and electron transfer activity. CYCS (Cytochrome C, Somatic) is a Protein Coding gene. In the process, it translocates four protons, helping to establish a chemiosmotic potential that the ATP synthase then uses to synthesize ATP. Cytochrome C in Electron Transport. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. It is an essential component of the electron transport chain (ETC), where it shuttles electrons to cytochrome c oxidase (COX) to eventually generate ATP. Cytochrome c contains a heme iron metal center that is essential to its function. Cytochrome c's primary structure comprises a chain of 100 amino acids. Two copper atoms, shown in green at the top, are thought to be the port for entry. It has recently been discovered that the release of cytochrome c from mitochondria into the cytoplasm is an important step in programmed cell death. During the electron transport process, this heme iron interconverts between the Fe 3+ and Fe 2+ oxidation states, which allows for electrons to be accepted and donated. This participation in apoptosis of eukaryotic cells is now considered to be another significant function of cytochrome c. Cytochrome c and c-type cytochromes occur in all eukaryotic organisms. Function. Cytochrome c oxidase uses several metal ions to shuffle electrons onto oxygen molecules. However, when a cell receives an apoptotic stimulus, cytochrome c is released into the cytosol and triggers programmed cell death through apoptosis. Cytochrome-c plays a key part in electron transport associated with aerobic cellular respiration.. Cytochrome-c is a small heme protein which is associated with the inner membrane of the mitochondria.In the electron transport process it transfers electrons between Complex III and Complex IV. 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